en انگل شناسی Parasitology گزارش مورد Case Report <div><strong>ABSTRACT</strong><br> <strong>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Background and Objective:</strong><em> Strongyloides</em> infection is usually asymptomatic in healthy individuals; however, immunocompromised patients are subject to potential hyperinfection involvement. Hereby, we report disseminated and hyperinfection strongyloidiasis in two immunosuppressed patients from north of Iran, an endemic region for <em>Strongyloides stercoralis</em>.<br> &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; <strong>Case description: </strong>After assessment of clinical symptoms, disseminated strongyloidiasis &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;was identified in the first case with pemphigus vulgaris by the presence of abundant larvae in direct stool smears and gastric biopsy. The second patient had metastatic carcinoma and was hospitalized with complicated symptoms. The infection was diagnosed by detection of numerous first-stage larvae in wet mount stool smears and agar plate analysis. Despite antiparasitic treatment, both patients died during the hospitalization.<br> <strong>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; </strong><strong>Conclusion:</strong> Delayed diagnosis of active strongyloidiasis in immunosuppressed patients can lead to hyperinfection syndrome. Thus, screening for <em>S. stercoralis</em> infection in these patients is recommended in endemic regions to reduce mortalities.<br> <strong>&nbsp;&nbsp; &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</strong><strong>Keywords:</strong> <em>Strongyloides stercoralis,</em> Disseminated strongyloidiasis, Hyperinfection.</div> Strongyloides stercoralis, Disseminated strongyloidiasis, Hyperinfection 51 54 http://mlj.goums.ac.ir/browse.php?a_code=A-10-648-2&slc_lang=en&sid=1 AhmadReza Meamar meamar.ar@iums.ac.ir 100319475328460016636 100319475328460016636 No Department of Parasitology and Mycology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran Nahid jalallou nahidjalallou@yahoo.com 100319475328460016637 100319475328460016637 Yes Department of Medical Laboratory Science, AJA University of Medical Sciences, Tehran, Iran Leila Masoori leilamasoori@gmail.com 100319475328460016638 100319475328460016638 No Department of Parasitology and Mycology, School of Medicine, Iran University of Medical Sciences Maryam Alipour alipour,m@iums.ac.ir 100319475328460016639 100319475328460016639 No Department of Parasitology and Mycology, School of Medicine, Iran University of Medical Sciences