en خون شناسی آزمایشگاهی و بانک خون Laboratory hematology تحقيقي Original Paper <strong>Background and objectives:</strong> Acute myeloid leukemia (AML) is a malignancy that involves the bone marrow and peripheral blood. Some chemokines play a role in the progression, migration and tumor initiation and are therefore associated with poor prognosis. CCL2 promotes tumor growth and is associated with poor prognosis in AML patients. We investigated effects of chemotherapy on serum level of CCL2 in AML patients.<br> <strong>Methods: </strong>Throughout this case-control study, blood samples were collected from 25 healthy individuals and 25 AML (M4 and M5) patients before and after the first stage of the current chemotherapy regimen (7+3). Serum level of CCL2 was measured using commercial ELISA kits. Data were analyzed in SPSS 22 using the two-sample t-test and paired t-test.<br> <strong>Results:</strong> Before chemotherapy, serum level of CCL2 was significantly higher in the patients than in the healthy controls. Following chemotherapy, the serum level of CCL2 reduced significantly to a level comparable to that of the healthy controls.<br> <strong>Conclusion:</strong> The current chemotherapy (7+3) can effectively inhibit CCL2 in AML patients. Leukemia, Myeloid, Acute,Chemokine CCL2,Chemokines, 9 14 http://mlj.goums.ac.ir/browse.php?a_code=A-10-935-2&slc_lang=en&sid=1 Bahar Yazdani yazdani_zinat@yahoo.com 100319475328460019910 100319475328460019910 No Department of Hematology and blood banking, Kerman University of Medical Sciences, Kerman-Iran Hussein Anani anani.hossein@gmail.com 100319475328460019911 100319475328460019911 No Department of Hematology and blood banking, Kerman University of Medical Sciences, Kerman-Iran iman baluchi imanbaloochi7175@gmail.com 100319475328460019912 100319475328460019912 No Department of Hematology and blood banking, Kerman University of Medical Sciences, Kerman-Iran Behjat Kalantary Khandany dkalantarikhandani@gmail.com 100319475328460019913 100319475328460019913 No Hematooncologist, Assistant Professor in the Department of Medicine at Kerman University of Medical Sciences, Kerman, Iran Gholamhossein Hassanshahi bahar13671023@gmail.com 100319475328460019914 100319475328460019914 Yes Department of Hematology and blood banking, Kerman University of Medical Sciences, Kerman-Iran, Molecular Medicine Research Center, Institute of Basic Medical Sciences Research, Rafsanjan University of Medical Sciences, Rafsanjan-Iran