en فیزیولوژی ورزشی Sport Physiology تحقيقي Original Paper <div style="text-align: justify;"><span style="font-size:12px;"><span style="font-family:Times New Roman;"><span style="line-height:200%"><span new="" roman="" times=""><b>Background:</b>&nbsp;<strong>Endurance exercise causes fatigue due to mitochondrial dysfunction and oxidative stress.</strong> The present study was designed to investigate the effects of taurine supplementation on lipids peroxidation and antioxidant activity during endurance activities.&nbsp;</span></span><br> <span style="line-height:200%"><span new="" roman="" times=""><b>Methods:</b>&nbsp;Twenty-four male volunteers aged 27 &plusmn; 1.8 years and weighting 74.9 &plusmn; 5.9 kg were randomly divided into three groups: taurine supplementation (n=8), placebo (n=8), and control (n=8). The subjects completed a 28-day endurance training protocol. Biochemical parameters such as superoxide dismutase (SOD), glutathione peroxidase (GPX) activities, as well as malondialdehyde (MDA) concentrations (8 hours before the first session and 8 hours after the last session) and maximum rate of oxygen consumption, were measured to evaluate the antioxidant, lipid peroxidation, and VO₂max status respectively. Finally, data were analyzed by SPSS software at a significance level of <0.05.</span></span><br> <span style="line-height:200%"><span new="" roman="" times=""><b>Results:</b>&nbsp;Taurine supplementation significantly increased SOD (<i>p</i>=0.001) and GPX (<i>p</i>=0.001) but significantly decreased MDA (<i>p</i>=0.001). However, it had no significant effect on the VO₂max.&nbsp;</span></span><br> <span style="line-height:200%"><span new="" roman="" times=""><b>Conclusion:</b>&nbsp;The results of the present study indicate that taurine has antioxidant effects against endurance exercise-induced oxidant stress and lipid peroxidation.</span></span></span></span></div> Glutathione peroxidase,Superoxide dismutase,male,Taurine, 38 44 http://mlj.goums.ac.ir/browse.php?a_code=A-10-987-1&slc_lang=en&sid=1 sajad jafari S.jafari2022@gmail.com 100319475328460032006 100319475328460032006 No Department of Physical Education and sport sciences, Lorestan University, Khorammabad, Iran mohammad fathi fathi.m@lu.ac.ir 100319475328460032007 100319475328460032007 Yes Department of Physical Education and sport sciences, Lorestan University, Khorammabad, Iran masoud Rahmati rahmati.mas@lu.ac.ir 100319475328460032008 100319475328460032008 No Department of Physical Education and sport sciences, Lorestan University, Khorammabad, Iran