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Showing 2 results for Septicemia
Antimicrobial Susceptibility of Bacterial Agent in Hospitalized Neonates in Intensive Care Unit in Bahrami Hospital of Tehran, Iran
Mm Soltan Dallal, Z Rajabi,
Volume 9, Issue 3 (9-2015)
Abstract

Abstract

Background and Objective: This study aimed to investigate the antimicrobial susceptibility of the most common pathogens in hospitalized neonates in Intensive Care Unit.

Material and Methods: In this one-year descriptive study, 150 blood samples of neonates in Intensive Care Unit of Bahrami hospital of Tehran were divided into two groups of early onset sepsis (the first 72 hours of life) and   late onset sepsis (after the 72 hours of life). After isolating and identifying of bacteria, their antibiotics susceptibility was studied by Kirby- bauer method in accordance with CLSI guidelines.

Result: The most isolated organisms were Klebsiella pneumoniae (41.3%).  Coagulase negative staphylococcus was the cause of early onset septicemia and Klebsiella pneumoniae of both early and late onset septicemia. The highest susceptibility in gram-negative microorganisms was shown to Ciprofloxacin (89.6%) and in gram positive to Vancomycin (82.8%).

Conclusion: Gram-negative bacteria are the main cause of contamination in NICU and ciprofloxacin is the most effective antibiotic. Thus, it is imperative that NICU should be extremely controlled.

Keywords: Septicemia; Antibiotic Susceptibility; Neonatal Intensive Care Unit


Outbreak of Burkholderia gladioli septicemia in a neonatal intensive care unit: Investigation and control measures
Karvi Agarwal , Amit Garg, Konpal Agarwal , Naila Begum ,
Volume 20, Issue 2 (3-2026)
Abstract
Background: Burkholderia gladioli (B. gladioli) is a rare but emerging pathogen associated with neonatal sepsis. This case series describes the investigation and control of an outbreak in a tertiary neonatal intensive care unit (NICU) in India.
Methods: In January 2024, seven neonates admitted to the NICU developed bloodstream infections. Clinical manifestations included respiratory distress, feeding refusal, metabolic acidosis, seizures, and shock. Predisposing factors included prematurity, congenital anomalies, and perinatal asphyxia. Blood cultures were processed using the automated BD BactecFX-40 system, and organism identification with antimicrobial susceptibility testing was performed using the BD Phoenix M-50 system. Environmental sampling was conducted to identify the outbreak source.
Results: Of 72 blood culture bottles, 34 (47.2%) flagged positive. B. gladioli were isolated from seven patients, accounting for 20.6% of positive cultures. The overall mortality rate was 57.1% (4/7 Deaths). All clinical isolates showed identical susceptibility patterns, with susceptibility to levofloxacin, cotrimoxazole, ceftazidime, chloramphenicol, minocycline, and meropenem, and intrinsic resistance to colistin. Environmental surveillance identified the same B. gladioli strain from suction apparatus and phototherapy units. Contributory factors included poor hand hygiene compliance (28-33%), limited glove availability, and overcrowding. Following cohorting, deep cleaning with 1% hypochlorite, staff retraining, and reinforcement of infection control protocols, no further isolates were recovered.
Conclusion: This outbreak highlights the high mortality associated with B. gladioli sepsis in neonates and underscores the critical need for stringent infection control practices and automated identification systems in NICUs. To our knowledge, this is the first such report from India.

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