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Showing 3 results for Trichomonas Vaginalis
Prevalence of Trichomonas Vaginalis in Diabetic Females
N Nazari, Ma Rahimi, E Bayat,
Volume 8, Issue 3 (8-2014)
Abstract
Abstract Background and Objective: Trichomonas vaginalis is a pathogenic agent known worldwide and affects about 180 million annually. We aimed to investigate the prevalence of Trichomonas vaginalis in diabetic patients referred to diabetic research center. Material and Methods: In this descriptive-analytic study, 215 women referring to the Diabetic Center in Kermanshah Province were investigated for Trichomonas vaginalis. After collecting the data by a questionnaire, the samples were obtained from posterior fornix by sterile swabs and sent for assessing by direct microscopy and Dorset medium. Results: Totally, 1.3 percent of the women were confirmed to be infected with T. vaginalis. Conclusion: The range of blood sugar cannot remarkably affect the prevalence of T. vaginalis. Given the limitations of this study and low prevalence compared to similar studies, we recommend further comprehensive research for better understanding. Keywords: Trichomonas Vaginalis, Diabet, Prevalence
Preliminary phytochemical screening and antitrichomonal activity of Ferula pseudalliacea
Zarifeh Akbari , Dara Dastan , Mohammad Fallah , Amir Hossein Maghsood , Mohammad Matini ,
Volume 19, Issue 6 (11-2025)
Abstract
Background: Trichomonas vaginalis (T. vaginalis) causes human trichomoniasis, a common type of protozoan vaginitis. Due to the increasing incidence of drug-resistant trichomoniasis, new pharmacological research is needed. The aim was to investigate the activity of Ferula pseudalliacea (F. pseudalliacea) against T. vaginalis and to perform a preliminary phytochemical analysis of its extracts.
Methods: Essential oil and various extracts of F. pseudalliacea roots, including n-hexane, ethyl acetate, and methanol, were obtained. Susceptibility testing of the plant products was performed on five T. vaginalis isolates using the microtiter plate method. Minimum lethal concentration (MLC) and growth inhibitory percent (GI%) of sub-MLC concentrations were reported after 24- and 48-hour exposures. Phytochemical screening of the extracts was carried out using a standard procedure.
Results: The antitrichomonal effect of the plant products depended on time and concentration, with the greatest effect observed after 48 hours of exposure. The essential oil and n-hexane extract of F. pseudalliacea demonstrated remarkable activity with MLC of 250 µg/ml, followed by the ethyl acetate (MLC=500 µg/ml) and methanol extract (MLC=1000 µg/ml), with GI% 92.8, 50.6, 85.2, and 42.8, respectively. The bioactive constituents of the extracts were coumarins, terpenoids, steroids, phenols, tannins, and glycosides.
Conclusion: The results of this study demonstrated in vitro antitrichomonal properties of F. pseudalliacea. Therefore, further studies are needed to investigate the potential antitrichomonal activity of its bioactive constituents.

Trichomonas vaginalis and challenges to laboratory diagnosis: a narrative review
Hossein Hooshyar, Parvin Rostamkhani, Mohsen Arbabi,
Volume 20, Issue 2 (6-2026)
Abstract
Background and objectives: Trichomoniasis is considered as the most common non-viral sexually transmitted diseases globally. Early diagnosis of Trichomonas vaginalis infection has an important role in effective treatment and controlling the infection and interrupt of transmission chain. The present narrative review was carried out to gather new data and evaluate the challenges of available methods of laboratory of T. vaginalis diagnosis.
Methods: With a broad review of the published literature and electronic international databases such as ISI Web of Science, PubMed, Scopus, Science Direct, and Google Scholar was conducted to find relevant data reporting on existing and newly developed diagnostic methods for the identification of trichomoniasis diagnostic techniques in both sexes and covered 2000 up to 2025. The benefit and limitation of these methods were compared.
Results: This review article demonstrated wet mount preparation and examination under a light microscope accompanied by staining methods are the most frequently used worldwide. However, the sensitivity of this method is low. Direct microscopy examination accompanied by culturing or staining is a good-performance diagnostic strategy. Moreover, molecular and immunological-based methods are recommended to be used as complementary tests.
Conclusion: Direct microscopy examination is an economical and rapid method. The fully automated PCR system for the simultaneous identification of the most common vaginal pathogens can be established as a diagnostic strategy in non-endemic areas and developed countries.
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